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Mutagenesis Oxycodone hydrochloride was genotoxic in an in vitro mouse lymphoma assay while in the existence of metabolic activation. There was no evidence of genotoxic likely in an in vitro bacterial reverse mutation assay (Salmonella typhimurium and Escherichia coli) or in an assay for chromosomal aberrations (in vivo mouse bone marrow micronucle